InformedPeptides — Tools & Calculators
GLP-1 Dose Calculator
Select your medication, vial concentration, and prescribed dose — see exactly how many units to draw on a U-100 insulin syringe.
Unit Dose Calculator
For compounded vials — U-100 insulin syringe
1
Select medication
Units to Draw
—
units (U-100 syringe)
Volume
—
mL
Dose
—
mg
Syringe Fill Level
Draw to the — unit mark on your U-100 insulin syringe.
This equals — mL of your compounded vial.
A U-100 syringe holds 100 units = 1.0 mL total volume.
This equals — mL of your compounded vial.
A U-100 syringe holds 100 units = 1.0 mL total volume.
Standard Titration Schedules
Clinical dose escalation protocols for compounded GLP-1 medications. Always follow your prescribing provider's specific instructions — these are reference schedules only.
Semaglutide — Titration Schedule
| Weeks | Dose | Frequency | Phase | Notes |
|---|---|---|---|---|
| 1–4 | 0.25 mg | Once weekly | Loading | Initiation dose — not therapeutic for weight loss, minimizes GI side effects |
| 5–8 | 0.5 mg | Once weekly | Loading | First therapeutic dose — assess tolerability |
| 9–12 | 1.0 mg | Once weekly | Maintenance | Standard maintenance dose for many patients |
| 13–16 | 1.7 mg | Once weekly | Maintenance | Escalate if weight loss plateau at lower dose |
| 17+ | 2.4 mg | Once weekly | Maximum | Maximum approved dose (Wegovy). Only if tolerated and clinically indicated |
Tirzepatide — Titration Schedule
| Weeks | Dose | Frequency | Phase | Notes |
|---|---|---|---|---|
| 1–4 | 2.5 mg | Once weekly | Loading | Initiation dose — GI tolerability establishment |
| 5–8 | 5 mg | Once weekly | Loading | First maintenance-range dose |
| 9–12 | 7.5 mg | Once weekly | Maintenance | Escalate if well-tolerated and insufficient response |
| 13–16 | 10 mg | Once weekly | Maintenance | Standard upper maintenance dose |
| 17–20 | 12.5 mg | Once weekly | Maintenance | High-end maintenance — assess tolerability carefully |
| 21+ | 15 mg | Once weekly | Maximum | Maximum approved dose (Zepbound/Mounjaro) |
Retatrutide — Titration Schedule
| Weeks | Dose | Frequency | Phase | Notes |
|---|---|---|---|---|
| 1–4 | 1 mg | Once weekly | Loading | Initiation — triple agonist requires slower titration than semaglutide |
| 5–8 | 2 mg | Once weekly | Loading | GI tolerability assessment — glucagon component adds nausea risk |
| 9–12 | 4 mg | Once weekly | Maintenance | Therapeutic range begins |
| 13–16 | 6 mg | Once weekly | Maintenance | Phase 3 trial primary maintenance dose |
| 17–20 | 8 mg | Once weekly | Maintenance | Upper maintenance — shown superior weight loss vs lower doses |
| 21+ | 12 mg | Once weekly | Maximum | Maximum studied dose in Phase 3 trials. FDA approval pending — compounded use only currently. |
This calculator is for informational and educational purposes only. It does not constitute medical advice. GLP-1 medications require a valid prescription from a licensed healthcare provider. Compounded GLP-1 medications are not FDA-approved finished drug products. Always follow your prescribing provider's specific dosing instructions. InformedPeptides.com is not liable for actions taken based on this calculator.
Already running multiple peptides? Once you've nailed your dose, run your full stack through the Peptide Stack Analyzer → to surface mechanism overlap, redundancies, and gaps relative to your goal.
InformedPeptides
Dosing Protocol Calculator
Select your peptide, vial strength, and therapeutic goal — receive step-by-step reconstitution instructions and a tailored dosing schedule.
Protocol Builder
Three inputs. One complete protocol.
1
Select peptide
Reconstitution steps
Dosing schedule
Important
This protocol is for educational and research reference only. It does not constitute medical advice, diagnosis, or treatment. Peptide dosing should always be determined by a qualified, licensed healthcare provider based on your individual labs, health history, and clinical context. InformedPeptides.com and its authors are not liable for any actions taken based on the content of this tool.
How this tool works
Goal-based protocols
The same peptide serves different functions depending on your goal. Dosing, timing, and cycling guidance are all tailored to your specific objective.
Reconstitution done for you
BAC water volumes and resulting concentrations are pre-calculated for each vial strength. No manual math required.
Clinical source material
Protocols draw on peer-reviewed research, functional medicine practitioner guidance, and established clinical observations.